Chapter 5 · Book Chapter
Open Access
Peer Reviewed
Scaffold Design and Biodegradable Polymers in Tissue Engineering: Recent Advances, Clinical Translation, and Future Perspectives
Abstract
Biodegradable polymers have emerged as one of the most promising classes of biomaterials for tissue engineering and regenerative medicine because of their excellent biocompatibility, controlled biodegradation and ability to support cellular growth and tissue regeneration. This chapter comprehensively reviews the fundamental principles of tissue engineering, desirable scaffold characteristics, biodegradable polymer classifications and major scaffold fabrication techniques including electrospinning, freeze-drying, solvent casting, gas foaming and 3D/4D bioprinting, together with recent advances from 2024-2026 and current challenges in vascularisation, immune compatibility, degradation control, manufacturing and clinical translation.
Biodegradable polymersTissue engineeringRegenerative medicineDrug delivery systemsScaffold fabrication3D bioprinting
Author Affiliations
- 1 School of Pharmacy and Emerging Sciences (SPES), Baddi University, Makhnumajra, Baddi, District Solan, Himachal Pradesh-173205, India.
- 2 School of Pharmacy, Lingaya's Vidyapeeth (Deemed-to-be University), Faridabad, Haryana-121002, India.
How to Cite this Chapter
Saklani, S., & Goyal, A. (2026).
Scaffold Design and Biodegradable Polymers in Tissue Engineering: Recent Advances, Clinical Translation, and Future Perspectives. In A. P. Singh, A. Singh, P. Chahal, & P. Dhama (Eds.),
Biodegradable Polymers in Drug Delivery and Tissue Engineering (pp. 106–141). WiseLeaf Scientific Ventures.
https://doi.org/10.66079/wiseleaf.biodegradable-polymers.2026