Pyridine, Quinoline and Triazole Based Therapeutics
Corresponding author: [email protected]
Abstract
Heterocyclic compounds play a crucial role in pharmaceutical research and drug development because of their wide range of biological and therapeutic properties. Among the various heterocyclic systems, pyridine, quinoline and triazole rings are recognized as important pharmacophores found in numerous biologically active molecules and marketed drugs. These scaffolds possess unique structural and chemical characteristics that enable effective interaction with diverse biological targets. Pyridine derivatives have demonstrated significant therapeutic applications, including antimicrobial, anticancer, anti-inflammatory, antitubercular and cardiovascular activities. Quinoline-based compounds have been extensively investigated for their efficacy against malaria, microbial infections, cancer and several chronic diseases. Likewise, triazole derivatives are well known for their broad spectrum of pharmacological effects, particularly as antifungal, antibacterial, antiviral and anticancer agents. The presence of these heterocyclic moieties often enhances drug potency, selectivity and pharmacokinetic properties. Recent progress in synthetic chemistry, computational drug design and structure–activity relationship studies has facilitated the development of novel pyridine, quinoline and triazole derivatives with improved therapeutic profiles. This review focuses on the medicinal importance of these heterocyclic nuclei, highlighting their chemistry, biological activities and clinical relevance.
Author Affiliations
- 1 Assistant Professor, Department of Pharmaceutics, Godavari Shikshan Mandal's Asian Institute of Pharmacy, Nashik, India.