Academic Pharmacology PCI 2026 (NEP 2020) Paid Access

General Pharmacology (Practical)

By Praveen Rao & Poorva Girotra

A laboratory manual for BP309P, B. Pharm Semester III, written to the new Pharmacy Council of India syllabus 2026 (NEP 2020). The exercises are performed on validated computer simulations rather than live animals, in keeping with the 6Rs of humane experimentation, CCSEA rules, and OECD and ICH guidance. Every experiment follows the same sequence of Aim, Requirements, Principle, Procedure, Observations, Calculations, Result, Precautions and Viva-Voce, so that the theory of drug action becomes a set of measurements the student can actually record and interpret.
Category
Pharmacology (Practical)
Target Audience
B. Pharm Semester III Students
Course Code
BP309P
Syllabus
PCI 2026 (NEP 2020)
ISBN
978-81-180383-1-3
Experiments
18 Experiments

About This Book

General Pharmacology (Practical) turns the theory of drug action into a set of measurements. The manual opens with the history of experimental pharmacology, laboratory safety and hygiene, the instruments in common use, and the experimental and transgenic animals that pharmacology depends on, before moving to the ethical and regulatory framework of the 6Rs, CCSEA rules and OECD and ICH guidance.

Later experiments build quantitative skill: construction and interpretation of dose-response curves, the potentiating effect of physostigmine and the antagonising effect of d-tubocurarine on the response to acetylcholine, determination of PD2, estimation of LD50 by the OECD 425 method, calculation of pharmacokinetic parameters from hypothetical data, and software-based genotoxicity and teratogenicity testing. Specimen data tables are worked out in full so that the method of calculation is clear, while matching blank tables are left for the student's own observations, letting the volume serve as both a textbook to study from and a record book to write in.

List of Experiments

  1. Contributions of Renowned Pharmacologists (Nobel Laureates)
  2. Laboratory Safety, Hazards, Hygiene, and Common Instruments
  3. Common Experimental Animals and Transgenic Animals
  4. The 6Rs and Animal Maintenance under CCSEA Guidelines
  5. Collection and Isolation of DNA and RNA (Computer Simulation)
  6. Anaesthetics and Euthanasia Procedures for Experimental Animals
  7. Routes of Drug Administration and Maximum Administrable Dose (Simulation)
  8. Preparation of Physiological Salt Solutions and Cell-Culture Media
  9. Instrumentation for Isolated-Tissue Experiments (Student Organ-Bath Assembly)
  10. Dose–Response Curve of Two Agonists on an Isolated Tissue (Simulation)
  11. Potentiating Effect of Physostigmine on the DRC of Acetylcholine (Simulation)
  12. Antagonising Effect of d-Tubocurarine on the DRC of Acetylcholine (Simulation)
  13. Determination of PD2 of a Given Agonist (Simulation)
  14. Determination of Pharmacokinetic Parameters from Hypothetical Data
  15. Estimation of LD50 by the OECD 425 Method (Simulation)
  16. Software-Based Micronucleus and Chromosomal Aberration Test
  17. Software-Based Prediction of Teratogenicity
  18. UV-Spectrophotometric Study of Drug–Protein Interaction

Keywords

General Pharmacology BP309P Experimental Pharmacology Computer Simulation Dose–Response Curve LD50 OECD 425 PD2 Pharmacokinetic Parameters CCSEA Guidelines 6Rs of Humane Experimentation B. Pharm Semester III PCI Syllabus 2026 NEP 2020

How to Cite

Rao, P., & Girotra, P. (2026). General Pharmacology (Practical) (1st ed.). WiseLeaf Scientific Ventures. ISBN: 978-81-180383-1-3

DOI: 10.66079/wiseleaf.general-pharmacology-practical-bp309p.2026

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